Detailed information of TA system TA026519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1317460..1318114
• Replicon: chromosome
• Accession: NC_017325
• Organism: Sinorhizobium meliloti SM11

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: H0G1A3
• Locus tag: SM11_RS06330
• Protein ID: WP_003530010.1
• Coordinates: 1317926..1318114 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q92NX0
• Locus tag: SM11_RS06325
• Protein ID: WP_010969659.1
• Coordinates: 1317460..1317921 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM11_RS06300	1313595..1314038	+	444	WP_003529999.1	TIGR02594 family protein	-
SM11_RS06305	1314189..1315295	+	1107	WP_003530001.1	endonuclease	-
SM11_RS06310	1315298..1316047	+	750	WP_010969660.1	NUDIX hydrolase	-
SM11_RS06315	1316224..1317141	+	918	WP_003530005.1	PhzF family phenazine biosynthesis protein	-
SM11_RS06325	1317460..1317921	-	462	WP_010969659.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SM11_RS06330	1317926..1318114	-	189	WP_003530010.1	type II toxin-antitoxin system HicA family toxin	Toxin
SM11_RS06335	1318291..1319061	+	771	WP_010969658.1	hypothetical protein	-
SM11_RS06340	1319242..1320213	+	972	WP_017265202.1	glycosyltransferase family 2 protein	-
SM11_RS06345	1320238..1321548	-	1311	WP_010969656.1	HlyD family type I secretion periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6971.15 Da
• Isoelectric Point: 11.0889

>T26519 WP_003530010.1 NC_017325:c1318114-1317926 [Sinorhizobium meliloti SM11]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T26519 NC_017325:c1318114-1317926 [Sinorhizobium meliloti SM11]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 16293.17 Da
• Isoelectric Point: 4.3990

>AT26519 WP_010969659.1 NC_017325:c1317921-1317460 [Sinorhizobium meliloti SM11]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Nucleotide

• Length: 462 bp

>AT26519 NC_017325:c1317921-1317460 [Sinorhizobium meliloti SM11]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Structures

Toxin

• AlphaFold DB: H0G1A3

Antitoxin

• AlphaFold DB: Q92NX0