Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1374120..1374896 Replicon chromosome
Accession NZ_CP113018
Organism Staphylococcus aureus strain Taliyah

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS090_RS07365 Protein ID WP_000031108.1
Coordinates 1374744..1374896 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS090_RS07360 Protein ID WP_001251224.1
Coordinates 1374120..1374719 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS090_RS07340 (1370036) 1370036..1371493 + 1458 WP_000649907.1 ABC transporter permease subunit -
OS090_RS07345 (1371486) 1371486..1372208 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS090_RS07350 (1372359) 1372359..1373486 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS090_RS07355 (1373491) 1373491..1373961 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS090_RS07360 (1374120) 1374120..1374719 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS090_RS07365 (1374744) 1374744..1374896 + 153 WP_000031108.1 SAS053 family protein Toxin
OS090_RS07370 (1375673) 1375673..1376068 + 396 WP_000901021.1 hypothetical protein -
OS090_RS07375 (1376264) 1376264..1377649 + 1386 WP_000116224.1 class II fumarate hydratase -
OS090_RS07380 (1378112) 1378112..1378933 - 822 WP_000669375.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265187 WP_000031108.1 NZ_CP113018:1374744-1374896 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265187 WP_001251224.1 NZ_CP113018:1374120-1374719 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References