265182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1101964..1102493 Replicon chromosome
Accession NZ_CP113018
Organism Staphylococcus aureus strain Taliyah

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS090_RS05555 Protein ID WP_000621175.1
Coordinates 1102131..1102493 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS090_RS05550 Protein ID WP_000948331.1
Coordinates 1101964..1102134 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS090_RS05520 (1097001) 1097001..1097561 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
OS090_RS05525 (1097769) 1097769..1098248 + 480 WP_001287088.1 hypothetical protein -
OS090_RS05530 (1098241) 1098241..1099824 + 1584 WP_001294626.1 PH domain-containing protein -
OS090_RS05535 (1099811) 1099811..1100302 + 492 WP_001205910.1 PH domain-containing protein -
OS090_RS05540 (1100306) 1100306..1100665 + 360 WP_000581200.1 holo-ACP synthase -
OS090_RS05545 (1100731) 1100731..1101879 + 1149 WP_001281145.1 alanine racemase -
OS090_RS05550 (1101964) 1101964..1102134 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS090_RS05555 (1102131) 1102131..1102493 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS090_RS05560 (1102842) 1102842..1103843 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS090_RS05565 (1103962) 1103962..1104288 + 327 WP_001052491.1 anti-sigma factor antagonist -
OS090_RS05570 (1104290) 1104290..1104769 + 480 WP_001190829.1 anti-sigma B factor RsbW -
OS090_RS05575 (1104744) 1104744..1105514 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265182 WP_000621175.1 NZ_CP113018:1102131-1102493 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265182 WP_000948331.1 NZ_CP113018:1101964-1102134 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References