Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1085643..1086129 Replicon chromosome
Accession NC_017325
Organism Sinorhizobium meliloti SM11

Toxin (Protein)


Gene name - Uniprot ID F7X3C4
Locus tag SM11_RS05160 Protein ID WP_014529257.1
Coordinates 1085866..1086129 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7X3C3
Locus tag SM11_RS05155 Protein ID WP_014529256.1
Coordinates 1085643..1085879 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM11_RS05140 1081764..1083149 + 1386 WP_010969774.1 aldehyde dehydrogenase family protein -
SM11_RS05145 1083146..1084291 + 1146 WP_010969773.1 iron-containing alcohol dehydrogenase -
SM11_RS05150 1084496..1085659 - 1164 WP_017266410.1 site-specific integrase -
SM11_RS05155 1085643..1085879 - 237 WP_014529256.1 hypothetical protein Antitoxin
SM11_RS05160 1085866..1086129 - 264 WP_014529257.1 BrnT family toxin Toxin
SM11_RS05165 1086195..1086443 - 249 WP_014529258.1 hypothetical protein -
SM11_RS05170 1086440..1086637 - 198 WP_014529259.1 hypothetical protein -
SM11_RS05175 1086634..1086903 - 270 WP_017272640.1 hypothetical protein -
SM11_RS05180 1086878..1087669 - 792 WP_014529261.1 hypothetical protein -
SM11_RS39355 1087666..1087836 - 171 WP_014529262.1 hypothetical protein -
SM11_RS05185 1087833..1088345 - 513 WP_014529263.1 hypothetical protein -
SM11_RS05190 1088409..1089359 - 951 WP_014529264.1 recombinase RecT -
SM11_RS05195 1089356..1090357 - 1002 WP_014529265.1 hypothetical protein -
SM11_RS05200 1090541..1090984 - 444 WP_014529266.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 983700..1213345 229645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10042.37 Da        Isoelectric Point: 5.6343

>T26518 WP_014529257.1 NC_017325:c1086129-1085866 [Sinorhizobium meliloti SM11]
MDFEFDPPKSATNLEKHGIDFDAAQALWLDERLLEVPAKTEDEPRFLAIGQIGGKHWTAVFTYRGTAIRIISVRRARKQE
IEHYESL

Download         Length: 264 bp

>T26518 NC_017325:c1086129-1085866 [Sinorhizobium meliloti SM11]
ATGGACTTCGAATTTGACCCACCCAAGAGCGCCACGAACCTTGAAAAGCACGGCATCGACTTTGATGCCGCGCAGGCCCT
CTGGCTCGATGAACGGCTGTTGGAAGTCCCTGCGAAAACCGAAGATGAGCCCCGCTTTCTGGCAATAGGCCAGATCGGCG
GCAAGCACTGGACAGCGGTTTTCACCTATCGTGGCACAGCCATTCGGATCATTTCGGTGCGCCGCGCCCGGAAACAGGAG
ATAGAGCACTATGAAAGCCTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8877.92 Da        Isoelectric Point: 5.0900

>AT26518 WP_014529256.1 NC_017325:c1085879-1085643 [Sinorhizobium meliloti SM11]
MKASEFDRRFDAGEDITDAVDWDKAQRPNLEPHRVNVDFPSWVVGKLDQEAQRLGITRQALIKVWIADRLEGRNGAAS

Download         Length: 237 bp

>AT26518 NC_017325:c1085879-1085643 [Sinorhizobium meliloti SM11]
ATGAAAGCCTCTGAATTTGACCGGCGCTTTGATGCCGGCGAGGATATCACCGACGCGGTTGATTGGGATAAGGCGCAGCG
CCCCAATCTGGAGCCCCATCGCGTCAATGTCGATTTCCCTTCGTGGGTGGTTGGGAAATTGGACCAAGAGGCGCAGCGCT
TGGGGATCACCCGGCAAGCGCTGATTAAGGTGTGGATCGCCGATCGGCTGGAGGGGCGAAATGGCGCAGCATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F7X3C4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6S938

References