Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 156203..156732 Replicon chromosome
Accession NZ_CP113016
Organism Staphylococcus aureus strain Azir

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS077_RS00800 Protein ID WP_000621175.1
Coordinates 156203..156565 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS077_RS00805 Protein ID WP_000948331.1
Coordinates 156562..156732 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS077_RS00780 153181..153951 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
OS077_RS00785 153926..154405 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS077_RS00790 154407..154733 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS077_RS00795 154852..155853 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS077_RS00800 156203..156565 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS077_RS00805 156562..156732 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS077_RS00810 156817..157965 - 1149 WP_001281154.1 alanine racemase -
OS077_RS00815 158031..158390 - 360 WP_000581197.1 holo-ACP synthase -
OS077_RS00820 158394..158885 - 492 WP_072353916.1 PH domain-containing protein -
OS077_RS00825 158872..160455 - 1584 WP_001294626.1 PH domain-containing protein -
OS077_RS00830 160448..160927 - 480 WP_031590204.1 hypothetical protein -
OS077_RS00835 161136..161696 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265164 WP_000621175.1 NZ_CP113016:c156565-156203 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp


Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265164 WP_000948331.1 NZ_CP113016:c156732-156562 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References