Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2964442..2964956 Replicon chromosome
Accession NZ_CP113015
Organism Staphylococcus aureus strain Zed

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS078_RS15330 Protein ID WP_000581792.1
Coordinates 2964442..2964651 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS078_RS15335 Protein ID WP_000138932.1
Coordinates 2964663..2964956 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS078_RS15310 (2959950) 2959950..2961308 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS078_RS15315 (2961323) 2961323..2962393 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS078_RS15320 (2962711) 2962711..2963913 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS078_RS15325 (2964177) 2964177..2964314 - 138 WP_000828354.1 Lmo0850 family protein -
OS078_RS15330 (2964442) 2964442..2964651 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS078_RS15335 (2964663) 2964663..2964956 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS078_RS15340 (2965122) 2965122..2966606 + 1485 WP_000571549.1 cardiolipin synthase -
OS078_RS15345 (2966634) 2966634..2967281 + 648 WP_001187629.1 HD domain-containing protein -
OS078_RS15350 (2968094) 2968094..2968966 - 873 WP_000725802.1 membrane protein insertase YidC -
OS078_RS15355 (2969052) 2969052..2969693 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265160 WP_000581792.1 NZ_CP113015:c2964651-2964442 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265160 WP_000138932.1 NZ_CP113015:c2964956-2964663 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References