Detailed information of TA system TA026516

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 483453..484093
• Replicon: chromosome
• Accession: NC_017325
• Organism: Sinorhizobium meliloti SM11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H0G6N1
• Locus tag: SM11_RS02250
• Protein ID: WP_003533691.1
• Coordinates: 483453..483839 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H0G6N0
• Locus tag: SM11_RS02255
• Protein ID: WP_003533689.1
• Coordinates: 483839..484093 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM11_RS02225	478917..479396	+	480	WP_003537307.1	GNAT family N-acetyltransferase	-
SM11_RS02230	479440..479889	-	450	WP_003537305.1	nucleoside deaminase	-
SM11_RS02235	479964..481685	+	1722	WP_010968830.1	pseudouridine synthase	-
SM11_RS02240	481692..482252	+	561	WP_010968831.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SM11_RS02245	482325..483224	+	900	WP_010968832.1	patatin-like phospholipase family protein	-
SM11_RS02250	483453..483839	-	387	WP_003533691.1	type II toxin-antitoxin system VapC family toxin	Toxin
SM11_RS02255	483839..484093	-	255	WP_003533689.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
SM11_RS02260	484232..486064	-	1833	WP_014529072.1	monovalent cation:proton antiporter-2 (CPA2) family protein	-
SM11_RS02265	486216..487562	+	1347	WP_014529073.1	TldD/PmbA family protein	-
SM11_RS02270	487671..488489	+	819	WP_010968835.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
SM11_RS02275	488550..488786	+	237	WP_003533684.1	DUF4170 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13904.77 Da
• Isoelectric Point: 4.5716

>T26516 WP_003533691.1 NC_017325:c483839-483453 [Sinorhizobium meliloti SM11]
MVIDTSAIAAIAFNEQEAGSFREKIADDPVRLISAATALEAAMVIETRLGEAAGAELDLWLYKANVEIVAVTAEHMDQAR
RAWRRFGKGRHPAGLNFGDCFSYALAFLTNEPLLFKGSDFSQTDIPAA

Nucleotide

• Length: 387 bp

>T26516 NC_017325:c483839-483453 [Sinorhizobium meliloti SM11]
ATGGTCATCGACACATCCGCCATTGCCGCGATTGCCTTCAATGAACAGGAGGCCGGAAGTTTCCGCGAAAAAATCGCGGA
CGACCCGGTTCGGCTCATCTCCGCGGCAACCGCTCTGGAAGCGGCCATGGTAATCGAAACCCGGTTAGGCGAAGCTGCCG
GAGCGGAACTTGATCTTTGGCTTTACAAGGCAAACGTGGAGATTGTTGCGGTAACCGCCGAGCATATGGACCAGGCCCGC
CGTGCCTGGCGCCGTTTCGGCAAAGGCCGTCATCCGGCCGGTTTGAATTTCGGTGATTGTTTTTCCTATGCCCTGGCCTT
TCTGACAAATGAACCGCTTCTCTTCAAGGGAAGCGATTTCTCGCAAACCGATATCCCGGCGGCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9472.63 Da
• Isoelectric Point: 4.8660

>AT26516 WP_003533689.1 NC_017325:c484093-483839 [Sinorhizobium meliloti SM11]
MALSIKDTETEQLARTLARRTGESITLATKRALEERLRRTDTAARRAALLEDLEAIQRRWNAMPVLDSRSSDDIIGYDED
GLPS

Nucleotide

• Length: 255 bp

>AT26516 NC_017325:c484093-483839 [Sinorhizobium meliloti SM11]
ATGGCGCTGAGCATCAAGGACACTGAAACCGAGCAGCTTGCCCGCACACTTGCCCGGCGGACAGGGGAATCCATCACGCT
TGCCACCAAGCGTGCCCTCGAAGAACGATTGCGCCGAACCGACACCGCTGCCCGGCGCGCGGCTCTTCTGGAGGATCTGG
AAGCCATTCAACGCCGCTGGAATGCCATGCCCGTCCTCGACAGTCGCAGCTCCGATGACATTATCGGTTATGACGAGGAT
GGACTCCCCTCATAA

Structures

Toxin

• AlphaFold DB: H0G6N1

Antitoxin

• AlphaFold DB: H0G6N0