Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2944686..2945215 Replicon chromosome
Accession NZ_CP113015
Organism Staphylococcus aureus strain Zed

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS078_RS15240 Protein ID WP_000621175.1
Coordinates 2944686..2945048 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS078_RS15245 Protein ID WP_000948331.1
Coordinates 2945045..2945215 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS078_RS15220 (2941665) 2941665..2942435 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
OS078_RS15225 (2942410) 2942410..2942889 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS078_RS15230 (2942891) 2942891..2943217 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS078_RS15235 (2943336) 2943336..2944337 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS078_RS15240 (2944686) 2944686..2945048 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS078_RS15245 (2945045) 2945045..2945215 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS078_RS15250 (2945300) 2945300..2946448 - 1149 WP_001281145.1 alanine racemase -
OS078_RS15255 (2946514) 2946514..2946873 - 360 WP_000581200.1 holo-ACP synthase -
OS078_RS15260 (2946877) 2946877..2947368 - 492 WP_001205910.1 PH domain-containing protein -
OS078_RS15265 (2947355) 2947355..2948938 - 1584 WP_001294626.1 PH domain-containing protein -
OS078_RS15270 (2948931) 2948931..2949410 - 480 WP_001287088.1 hypothetical protein -
OS078_RS15275 (2949618) 2949618..2950178 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265159 WP_000621175.1 NZ_CP113015:c2945048-2944686 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265159 WP_000948331.1 NZ_CP113015:c2945215-2945045 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References