Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1922232..1922746 Replicon chromosome
Accession NZ_CP113009
Organism Staphylococcus aureus strain Orianna

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS092_RS09995 Protein ID WP_000581792.1
Coordinates 1922232..1922441 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS092_RS10000 Protein ID WP_000138932.1
Coordinates 1922453..1922746 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS092_RS09975 (1917740) 1917740..1919098 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS092_RS09980 (1919113) 1919113..1920183 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS092_RS09985 (1920501) 1920501..1921703 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS092_RS09990 (1921967) 1921967..1922104 - 138 WP_000828354.1 Lmo0850 family protein -
OS092_RS09995 (1922232) 1922232..1922441 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS092_RS10000 (1922453) 1922453..1922746 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS092_RS10005 (1922912) 1922912..1924396 + 1485 WP_000571549.1 cardiolipin synthase -
OS092_RS10010 (1924424) 1924424..1925071 + 648 WP_001187629.1 HD domain-containing protein -
OS092_RS10015 (1925884) 1925884..1926756 - 873 WP_000725802.1 membrane protein insertase YidC -
OS092_RS10020 (1926842) 1926842..1927483 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265140 WP_000581792.1 NZ_CP113009:c1922441-1922232 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265140 WP_000138932.1 NZ_CP113009:c1922746-1922453 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References