Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1628739..1629515 Replicon chromosome
Accession NZ_CP113009
Organism Staphylococcus aureus strain Orianna

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS092_RS08090 Protein ID WP_000031108.1
Coordinates 1628739..1628891 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS092_RS08095 Protein ID WP_001251224.1
Coordinates 1628916..1629515 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS092_RS08075 (1624702) 1624702..1625523 + 822 WP_000669375.1 RluA family pseudouridine synthase -
OS092_RS08080 (1625986) 1625986..1627371 - 1386 WP_000116224.1 class II fumarate hydratase -
OS092_RS08085 (1627567) 1627567..1627962 - 396 WP_000901021.1 hypothetical protein -
OS092_RS08090 (1628739) 1628739..1628891 - 153 WP_000031108.1 SAS053 family protein Toxin
OS092_RS08095 (1628916) 1628916..1629515 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS092_RS08100 (1629674) 1629674..1630144 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS092_RS08105 (1630149) 1630149..1631276 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS092_RS08110 (1631427) 1631427..1632149 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS092_RS08115 (1632142) 1632142..1633599 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265134 WP_000031108.1 NZ_CP113009:c1628891-1628739 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265134 WP_001251224.1 NZ_CP113009:c1629515-1628916 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References