Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1353086..1353862 Replicon chromosome
Accession NZ_CP113007
Organism Staphylococcus aureus strain Ryze

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS082_RS07065 Protein ID WP_000031108.1
Coordinates 1353710..1353862 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS082_RS07060 Protein ID WP_001251224.1
Coordinates 1353086..1353685 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS082_RS07040 (1349002) 1349002..1350459 + 1458 WP_000649907.1 ABC transporter permease subunit -
OS082_RS07045 (1350452) 1350452..1351174 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS082_RS07050 (1351325) 1351325..1352452 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS082_RS07055 (1352457) 1352457..1352927 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS082_RS07060 (1353086) 1353086..1353685 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS082_RS07065 (1353710) 1353710..1353862 + 153 WP_000031108.1 SAS053 family protein Toxin
OS082_RS07070 (1354639) 1354639..1355034 + 396 WP_000901021.1 hypothetical protein -
OS082_RS07075 (1355230) 1355230..1356615 + 1386 WP_000116224.1 class II fumarate hydratase -
OS082_RS07080 (1357078) 1357078..1357899 - 822 WP_000669375.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265126 WP_000031108.1 NZ_CP113007:1353710-1353862 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265126 WP_001251224.1 NZ_CP113007:1353086-1353685 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References