Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1080930..1081459 Replicon chromosome
Accession NZ_CP113007
Organism Staphylococcus aureus strain Ryze

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS082_RS05260 Protein ID WP_000621175.1
Coordinates 1081097..1081459 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS082_RS05255 Protein ID WP_000948331.1
Coordinates 1080930..1081100 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS082_RS05225 (1075967) 1075967..1076527 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
OS082_RS05230 (1076735) 1076735..1077214 + 480 WP_001287088.1 hypothetical protein -
OS082_RS05235 (1077207) 1077207..1078790 + 1584 WP_001294626.1 PH domain-containing protein -
OS082_RS05240 (1078777) 1078777..1079268 + 492 WP_001205910.1 PH domain-containing protein -
OS082_RS05245 (1079272) 1079272..1079631 + 360 WP_000581200.1 holo-ACP synthase -
OS082_RS05250 (1079697) 1079697..1080845 + 1149 WP_001281145.1 alanine racemase -
OS082_RS05255 (1080930) 1080930..1081100 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS082_RS05260 (1081097) 1081097..1081459 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS082_RS05265 (1081808) 1081808..1082809 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS082_RS05270 (1082928) 1082928..1083254 + 327 WP_001052491.1 anti-sigma factor antagonist -
OS082_RS05275 (1083256) 1083256..1083735 + 480 WP_001190829.1 anti-sigma B factor RsbW -
OS082_RS05280 (1083710) 1083710..1084480 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265121 WP_000621175.1 NZ_CP113007:1081097-1081459 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265121 WP_000948331.1 NZ_CP113007:1080930-1081100 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References