Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1061189..1061703 Replicon chromosome
Accession NZ_CP113007
Organism Staphylococcus aureus strain Ryze

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS082_RS05170 Protein ID WP_000581792.1
Coordinates 1061494..1061703 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS082_RS05165 Protein ID WP_000138932.1
Coordinates 1061189..1061482 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS082_RS05145 (1056452) 1056452..1057093 + 642 WP_000483153.1 thiamine phosphate synthase -
OS082_RS05150 (1057179) 1057179..1058051 + 873 WP_000725802.1 membrane protein insertase YidC -
OS082_RS05155 (1058864) 1058864..1059511 - 648 WP_001187629.1 HD domain-containing protein -
OS082_RS05160 (1059539) 1059539..1061023 - 1485 WP_000571549.1 cardiolipin synthase -
OS082_RS05165 (1061189) 1061189..1061482 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS082_RS05170 (1061494) 1061494..1061703 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS082_RS05175 (1061831) 1061831..1061968 + 138 WP_000828354.1 Lmo0850 family protein -
OS082_RS05180 (1062232) 1062232..1063434 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS082_RS05185 (1063752) 1063752..1064822 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS082_RS05190 (1064837) 1064837..1066195 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265120 WP_000581792.1 NZ_CP113007:1061494-1061703 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265120 WP_000138932.1 NZ_CP113007:1061189-1061482 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References