26511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 493430..494010 Replicon plasmid pSINMEB01
Accession NC_017324
Organism Sinorhizobium meliloti BL225C

Toxin (Protein)


Gene name vapC Uniprot ID Q92XP1
Locus tag SINMEB_RS19805 Protein ID WP_010968151.1
Coordinates 493430..493813 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F7XCL0
Locus tag SINMEB_RS19810 Protein ID WP_013851145.1
Coordinates 493810..494010 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINMEB_RS19775 489331..489777 - 447 WP_014528240.1 TIGR02588 family protein -
SINMEB_RS19780 489774..490448 - 675 Protein_475 TIGR02587 family membrane protein -
SINMEB_RS34115 490461..491404 - 944 Protein_476 IS630 family transposase -
SINMEB_RS34120 491490..491654 - 165 Protein_477 DUF2391 family protein -
SINMEB_RS19795 491987..492298 + 312 WP_014528242.1 hypothetical protein -
SINMEB_RS19800 492586..492981 - 396 WP_014528244.1 response regulator -
SINMEB_RS19805 493430..493813 - 384 WP_010968151.1 type II toxin-antitoxin system VapC family toxin Toxin
SINMEB_RS19810 493810..494010 - 201 WP_013851145.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SINMEB_RS19815 494526..495053 + 528 WP_014528245.1 TIGR02444 family protein -
SINMEB_RS19820 495244..496017 + 774 WP_014528246.1 UTRA domain-containing protein -
SINMEB_RS19825 496106..497482 - 1377 WP_014528247.1 NAD(P)/FAD-dependent oxidoreductase -
SINMEB_RS19830 497479..497793 - 315 WP_014528248.1 (2Fe-2S)-binding protein -
SINMEB_RS19835 497783..498889 - 1107 WP_014528249.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1616209 1616209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14292.54 Da        Isoelectric Point: 6.9172

>T26511 WP_010968151.1 NC_017324:c493813-493430 [Sinorhizobium meliloti BL225C]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN

Download         Length: 384 bp

>T26511 NC_017324:c493813-493430 [Sinorhizobium meliloti BL225C]
GTGATTCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATGCCGAGCTGCGTAGGATTATTGAGGACGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTTGCACTTGGCAGCCTTCGGGAACGCAGTAGCGTGATAGCATTCC
TGATGGCTCAGCGCGAAGCACTCGTCGCAACGCACCAGGAGGTCATGATGATGATCGATCGCCACGCCATTTTTAGCATG
GGGATTGGCTACACGGATGCCCATTTGCTGGCCTCGGTTCTCCTCGATCAGCGAATGGCTTTGTGGACGAGAGACAAGCG
TTTGCAGGCAGCGGCCGAAAAGGCGGGGGCGTCGCTGCACACCCCCGCCCATACGCGGAACTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7096.22 Da        Isoelectric Point: 11.1107

>AT26511 WP_013851145.1 NC_017324:c494010-493810 [Sinorhizobium meliloti BL225C]
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK

Download         Length: 201 bp

>AT26511 NC_017324:c494010-493810 [Sinorhizobium meliloti BL225C]
ATGCGATCGACTATCAACCTCGACGACACTCTCATGGAAAGGGCTAAGTCCCTAACCGGCACAAAAGAAACCGCCGCTCT
GGTCCGCCAGGCATTGGAGACGCTTGTTCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGGATG
CGGAAGCAGCTCCACGCCGCCGGAGCGCAGCTGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92XP1

Antitoxin

Source ID Structure
AlphaFold DB A0A7W6MID2

References