Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1750889..1751403 Replicon chromosome
Accession NZ_CP113005
Organism Staphylococcus aureus strain Galio

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS073_RS09330 Protein ID WP_000581792.1
Coordinates 1750889..1751098 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS073_RS09335 Protein ID WP_000138932.1
Coordinates 1751110..1751403 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS073_RS09310 (1746397) 1746397..1747755 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS073_RS09315 (1747770) 1747770..1748840 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS073_RS09320 (1749158) 1749158..1750360 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS073_RS09325 (1750624) 1750624..1750761 - 138 WP_000828354.1 Lmo0850 family protein -
OS073_RS09330 (1750889) 1750889..1751098 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS073_RS09335 (1751110) 1751110..1751403 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS073_RS09340 (1751569) 1751569..1753053 + 1485 WP_000571549.1 cardiolipin synthase -
OS073_RS09345 (1753081) 1753081..1753728 + 648 WP_001187629.1 HD domain-containing protein -
OS073_RS09350 (1754541) 1754541..1755413 - 873 WP_000725802.1 membrane protein insertase YidC -
OS073_RS09355 (1755499) 1755499..1756140 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265107 WP_000581792.1 NZ_CP113005:c1751098-1750889 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265107 WP_000138932.1 NZ_CP113005:c1751403-1751110 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References