26510

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 109523..110130 Replicon plasmid pSINMEB01
Accession NC_017324
Organism Sinorhizobium meliloti BL225C

Toxin (Protein)


Gene name hicA Uniprot ID A0A0E0UJ28
Locus tag SINMEB_RS17920 Protein ID WP_014528001.1
Coordinates 109523..109777 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID H0G1X1
Locus tag SINMEB_RS17925 Protein ID WP_003530441.1
Coordinates 109774..110130 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINMEB_RS17900 104923..105627 - 705 WP_014527995.1 haloacid dehalogenase type II -
SINMEB_RS17905 105718..106590 + 873 WP_014527996.1 LysR family transcriptional regulator -
SINMEB_RS37475 106642..106797 - 156 WP_017264742.1 hypothetical protein -
SINMEB_RS37480 106883..107041 - 159 WP_017267400.1 hypothetical protein -
SINMEB_RS17910 107165..108205 - 1041 WP_014527999.1 NAD(P)H-binding protein -
SINMEB_RS17915 108294..109181 + 888 WP_014528000.1 LysR family transcriptional regulator -
SINMEB_RS17920 109523..109777 + 255 WP_014528001.1 type II toxin-antitoxin system HicA family toxin Toxin
SINMEB_RS17925 109774..110130 + 357 WP_003530441.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SINMEB_RS17930 110566..111279 + 714 WP_014528002.1 3-keto-5-aminohexanoate cleavage protein -
SINMEB_RS17935 111570..112028 + 459 WP_014528003.1 helix-turn-helix domain-containing protein -
SINMEB_RS17940 112031..112621 + 591 WP_014528004.1 PIN domain-containing protein -
SINMEB_RS17945 112989..113645 - 657 WP_014528005.1 SGNH/GDSL hydrolase family protein -
SINMEB_RS17950 113675..114625 - 951 WP_010968047.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1616209 1616209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9246.58 Da        Isoelectric Point: 9.8124

>T26510 WP_014528001.1 NC_017324:109523-109777 [Sinorhizobium meliloti BL225C]
MNSKQRKTLAAVFKDPASGTIEWAAIENLLVAAGADVIEGNGSRVKVEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

>T26510 NC_017324:109523-109777 [Sinorhizobium meliloti BL225C]
ATGAACAGCAAGCAGAGAAAGACCCTCGCGGCCGTATTCAAGGACCCGGCCTCGGGAACGATTGAATGGGCCGCTATAGA
GAATCTGCTTGTGGCTGCCGGAGCGGACGTCATTGAGGGGAACGGTTCCCGCGTTAAGGTTGAAAAAGACGGCATCATTG
CGAGCTTTCATCGACCTCATCCGGACAAGGAAGCAAAGCGTTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13236.85 Da        Isoelectric Point: 4.9920

>AT26510 WP_003530441.1 NC_017324:109774-110130 [Sinorhizobium meliloti BL225C]
MNTMTYNGYHARIEFDAEDEVFFGKIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHFAEARLSA

Download         Length: 357 bp

>AT26510 NC_017324:109774-110130 [Sinorhizobium meliloti BL225C]
ATGAACACCATGACCTACAACGGGTATCACGCTCGCATCGAATTCGACGCTGAGGACGAAGTGTTTTTCGGCAAGATTGC
AGGTATCTCCGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCGGTCGATGACT
ACCTTGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTCAACCAGTGGGCAGAAGAGGTGCTGGAAGAAGC
CGCCGACCATTTTGCCGAGGCGCGCCTGTCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0UJ28

Antitoxin

Source ID Structure
AlphaFold DB H0G1X1

References