265097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3779782..3780467 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag ORO20_RS17765 Protein ID WP_003417998.1
Coordinates 3780057..3780467 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ORO20_RS17760 Protein ID WP_003912220.1
Coordinates 3779782..3780060 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS17740 (ORO20_17740) 3775771..3777372 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
ORO20_RS17745 (ORO20_17745) 3777389..3778093 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
ORO20_RS17750 (ORO20_17750) 3778211..3778777 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
ORO20_RS17755 (ORO20_17755) 3778839..3779726 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
ORO20_RS17760 (ORO20_17760) 3779782..3780060 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ORO20_RS17765 (ORO20_17765) 3780057..3780467 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO20_RS17770 (ORO20_17770) 3780500..3782236 - 1737 WP_003418002.1 cholesterol oxidase -
ORO20_RS17775 (ORO20_17775) 3782292..3783419 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
ORO20_RS17780 (ORO20_17780) 3783439..3785028 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T265097 WP_003417998.1 NZ_CP112997:3780057-3780467 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT265097 WP_003912220.1 NZ_CP112997:3779782-3780060 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References