Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3752352..3753019 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag ORO20_RS17645 Protein ID WP_003417916.1
Coordinates 3752352..3752744 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag ORO20_RS17650 Protein ID WP_003912214.1
Coordinates 3752744..3753019 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS17630 (ORO20_17630) 3747722..3749560 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
ORO20_RS17635 (ORO20_17635) 3749557..3750546 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
ORO20_RS17640 (ORO20_17640) 3750546..3751598 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
ORO20_RS17645 (ORO20_17645) 3752352..3752744 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO20_RS17650 (ORO20_17650) 3752744..3753019 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ORO20_RS17655 (ORO20_17655) 3753201..3754572 + 1372 Protein_3487 ISNCY family transposase -
ORO20_RS17660 (ORO20_17660) 3754762..3757005 + 2244 WP_268141921.1 PE family protein -
ORO20_RS17665 (ORO20_17665) 3757076..3757948 - 873 WP_268141923.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3753895..3754572 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T265096 WP_003417916.1 NZ_CP112997:c3752744-3752352 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT265096 WP_003912214.1 NZ_CP112997:c3753019-3752744 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References