Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3725230..3725759 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag ORO20_RS17525 Protein ID WP_003417760.1
Coordinates 3725502..3725759 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag ORO20_RS17520 Protein ID WP_003417757.1
Coordinates 3725230..3725505 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS17485 (ORO20_17485) 3721803..3722492 - 690 WP_003917774.1 BBE domain-containing protein -
ORO20_RS17490 (ORO20_17490) 3722679..3723050 - 372 WP_003417739.1 FAD-binding protein -
ORO20_RS17495 (ORO20_17495) 3722948..3723166 - 219 WP_157132559.1 hypothetical protein -
ORO20_RS17500 (ORO20_17500) 3723193..3723453 - 261 WP_003417741.1 hypothetical protein -
ORO20_RS17505 (ORO20_17505) 3723568..3723957 + 390 WP_010950876.1 DUF732 domain-containing protein -
ORO20_RS17510 (ORO20_17510) 3723971..3724264 - 294 WP_003417749.1 DUF3017 domain-containing protein -
ORO20_RS17515 (ORO20_17515) 3724261..3725106 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
ORO20_RS17520 (ORO20_17520) 3725230..3725505 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
ORO20_RS17525 (ORO20_17525) 3725502..3725759 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
ORO20_RS17530 (ORO20_17530) 3725801..3726991 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
ORO20_RS17535 (ORO20_17535) 3727108..3727476 + 369 WP_003417765.1 FHA domain-containing protein -
ORO20_RS17540 (ORO20_17540) 3727473..3728024 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
ORO20_RS17545 (ORO20_17545) 3728031..3728612 - 582 WP_003417769.1 ATP/GTP-binding protein -
ORO20_RS17550 (ORO20_17550) 3728593..3728961 - 369 WP_003417772.1 DUF742 domain-containing protein -
ORO20_RS17555 (ORO20_17555) 3728939..3729331 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T265095 WP_003417760.1 NZ_CP112997:3725502-3725759 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT265095 WP_003417757.1 NZ_CP112997:3725230-3725505 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References