Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3142550..3143237 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag ORO20_RS14965 Protein ID WP_003414624.1
Coordinates 3142794..3143237 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag ORO20_RS14960 Protein ID WP_003414620.1
Coordinates 3142550..3142807 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS14940 (ORO20_14940) 3137870..3138724 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
ORO20_RS14945 (ORO20_14945) 3138780..3139943 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
ORO20_RS14950 (ORO20_14950) 3139960..3141174 - 1215 WP_003414610.1 zinc metalloprotease Rip -
ORO20_RS14955 (ORO20_14955) 3141182..3142423 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
ORO20_RS14960 (ORO20_14960) 3142550..3142807 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
ORO20_RS14965 (ORO20_14965) 3142794..3143237 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO20_RS14970 (ORO20_14970) 3143317..3143979 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
ORO20_RS14975 (ORO20_14975) 3144075..3144266 + 192 WP_023349587.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
ORO20_RS14980 (ORO20_14980) 3144598..3146346 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
ORO20_RS14985 (ORO20_14985) 3146442..3147023 + 582 WP_003414644.1 fasciclin domain-containing protein -
ORO20_RS14990 (ORO20_14990) 3147123..3147389 + 267 WP_031652375.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T265092 WP_003414624.1 NZ_CP112997:3142794-3143237 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT265092 WP_003414620.1 NZ_CP112997:3142550-3142807 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References