Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3136949..3137497 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag ORO20_RS14935 Protein ID WP_003414602.1
Coordinates 3137234..3137497 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag ORO20_RS14930 Protein ID WP_003414599.1
Coordinates 3136949..3137230 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS14905 (ORO20_14905) 3132572..3133429 - 858 WP_003899513.1 type I methionyl aminopeptidase -
ORO20_RS14910 (ORO20_14910) 3133471..3134055 - 585 WP_010950792.1 DUF1707 domain-containing protein -
ORO20_RS14915 (ORO20_14915) 3134159..3134407 + 249 WP_003913411.1 antitoxin VapB23 -
ORO20_RS14920 (ORO20_14920) 3134404..3134784 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
ORO20_RS14925 (ORO20_14925) 3134866..3136677 - 1812 WP_003414596.1 penicillin-binding protein -
ORO20_RS14930 (ORO20_14930) 3136949..3137230 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
ORO20_RS14935 (ORO20_14935) 3137234..3137497 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ORO20_RS14940 (ORO20_14940) 3137870..3138724 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
ORO20_RS14945 (ORO20_14945) 3138780..3139943 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
ORO20_RS14950 (ORO20_14950) 3139960..3141174 - 1215 WP_003414610.1 zinc metalloprotease Rip -
ORO20_RS14955 (ORO20_14955) 3141182..3142423 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T265091 WP_003414602.1 NZ_CP112997:3137234-3137497 [Mycobacterium tuberculosis variant bovis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT265091 WP_003414599.1 NZ_CP112997:3136949-3137230 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References