Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN_Sll0205-like-Phd |
Location | 3096087..3096691 | Replicon | chromosome |
Accession | NZ_CP112997 | ||
Organism | Mycobacterium tuberculosis variant bovis strain 2016/0386 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P71623 |
Locus tag | ORO20_RS14735 | Protein ID | WP_003414492.1 |
Coordinates | 3096087..3096479 (-) | Length | 131 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A829CBY8 |
Locus tag | ORO20_RS14740 | Protein ID | WP_003414495.1 |
Coordinates | 3096476..3096691 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ORO20_RS14705 (ORO20_14705) | 3091237..3092025 | - | 789 | WP_193692467.1 | CRISPR-associated endoribonuclease Cas6 | - |
ORO20_RS14710 (ORO20_14710) | 3092359..3092904 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
ORO20_RS14715 (ORO20_14715) | 3093176..3094060 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
ORO20_RS14720 (ORO20_14720) | 3094063..3094950 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
ORO20_RS14725 (ORO20_14725) | 3095255..3095800 | - | 546 | WP_010950781.1 | DUF1802 family protein | - |
ORO20_RS14730 (ORO20_14730) | 3095797..3096066 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
ORO20_RS14735 (ORO20_14735) | 3096087..3096479 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
ORO20_RS14740 (ORO20_14740) | 3096476..3096691 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
ORO20_RS14745 (ORO20_14745) | 3096738..3097487 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
ORO20_RS14750 (ORO20_14750) | 3097566..3098648 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
ORO20_RS14755 (ORO20_14755) | 3098641..3099951 | - | 1311 | WP_031702645.1 | ABC transporter substrate-binding protein | - |
ORO20_RS14760 (ORO20_14760) | 3099954..3100781 | - | 828 | WP_003414504.1 | carbohydrate ABC transporter permease | - |
ORO20_RS14765 (ORO20_14765) | 3100778..3101688 | - | 911 | Protein_2914 | sugar ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14610.74 Da Isoelectric Point: 6.7594
>T265090 WP_003414492.1 NZ_CP112997:c3096479-3096087 [Mycobacterium tuberculosis variant bovis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
Download Length: 393 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BWM8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CBY8 |