Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2348766..2349461 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag ORO20_RS10970 Protein ID WP_003410811.1
Coordinates 2348766..2349200 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag ORO20_RS10975 Protein ID WP_003410814.1
Coordinates 2349207..2349461 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS10960 (ORO20_10960) 2344920..2347961 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
ORO20_RS10965 (ORO20_10965) 2347954..2348787 + 834 WP_003899172.1 SWIM zinc finger family protein -
ORO20_RS10970 (ORO20_10970) 2348766..2349200 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO20_RS10975 (ORO20_10975) 2349207..2349461 - 255 WP_003410814.1 antitoxin Antitoxin
ORO20_RS10980 (ORO20_10980) 2349477..2349734 - 258 WP_003410816.1 hypothetical protein -
ORO20_RS10985 (ORO20_10985) 2350681..2350977 + 297 WP_003410820.1 PE family protein -
ORO20_RS10990 (ORO20_10990) 2351033..2351764 + 732 WP_003900467.1 PPE family protein -
ORO20_RS10995 (ORO20_10995) 2352304..2353050 - 747 WP_003901330.1 proteasome subunit alpha -
ORO20_RS11000 (ORO20_11000) 2353047..2353922 - 876 WP_003411023.1 proteasome subunit beta -
ORO20_RS11005 (ORO20_11005) 2353919..2354113 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T265078 WP_003410811.1 NZ_CP112997:c2349200-2348766 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT265078 WP_003410814.1 NZ_CP112997:c2349461-2349207 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References