Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2307580..2308216 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag ORO20_RS10785 Protein ID WP_003410654.1
Coordinates 2307806..2308216 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag ORO20_RS10780 Protein ID WP_003410651.1
Coordinates 2307580..2307813 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS10765 (ORO20_10765) 2303037..2303429 + 393 WP_229303073.1 metal ABC transporter permease -
ORO20_RS10770 (ORO20_10770) 2303430..2303834 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
ORO20_RS10775 (ORO20_10775) 2303918..2307502 - 3585 WP_010950652.1 cobaltochelatase subunit CobN -
ORO20_RS10780 (ORO20_10780) 2307580..2307813 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
ORO20_RS10785 (ORO20_10785) 2307806..2308216 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
ORO20_RS10790 (ORO20_10790) 2308200..2309291 + 1092 WP_003900454.1 precorrin-3B synthase -
ORO20_RS10795 (ORO20_10795) 2309301..2309927 + 627 WP_003410658.1 precorrin-8X methylmutase -
ORO20_RS10800 (ORO20_10800) 2309924..2311450 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
ORO20_RS10805 (ORO20_10805) 2311396..2312619 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T265077 WP_003410654.1 NZ_CP112997:2307806-2308216 [Mycobacterium tuberculosis variant bovis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT265077 WP_003410651.1 NZ_CP112997:2307580-2307813 [Mycobacterium tuberculosis variant bovis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References