Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 2198148..2198692 | Replicon | chromosome |
Accession | NZ_CP112997 | ||
Organism | Mycobacterium tuberculosis variant bovis strain 2016/0386 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TLU9 |
Locus tag | ORO20_RS10265 | Protein ID | WP_003409896.1 |
Coordinates | 2198148..2198444 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P67299 |
Locus tag | ORO20_RS10270 | Protein ID | WP_003409899.1 |
Coordinates | 2198441..2198692 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ORO20_RS10210 (ORO20_10210) | 2193181..2193531 | - | 351 | WP_003409871.1 | hypothetical protein | - |
ORO20_RS10215 (ORO20_10215) | 2193542..2194444 | - | 903 | WP_003409874.1 | hypothetical protein | - |
ORO20_RS10220 (ORO20_10220) | 2194465..2194656 | - | 192 | WP_003409876.1 | hypothetical protein | - |
ORO20_RS10225 (ORO20_10225) | 2194657..2194953 | - | 297 | WP_003409877.1 | hypothetical protein | - |
ORO20_RS10230 (ORO20_10230) | 2195193..2195408 | + | 216 | WP_003409878.1 | antitoxin | - |
ORO20_RS10235 (ORO20_10235) | 2195405..2195716 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
ORO20_RS10240 (ORO20_10240) | 2195690..2196211 | - | 522 | WP_010950637.1 | hypothetical protein | - |
ORO20_RS10245 (ORO20_10245) | 2196186..2196563 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
ORO20_RS10250 (ORO20_10250) | 2196605..2197054 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
ORO20_RS10255 (ORO20_10255) | 2197051..2197596 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
ORO20_RS10260 (ORO20_10260) | 2197485..2198099 | - | 615 | WP_003901296.1 | hypothetical protein | - |
ORO20_RS10265 (ORO20_10265) | 2198148..2198444 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ORO20_RS10270 (ORO20_10270) | 2198441..2198692 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
ORO20_RS10275 (ORO20_10275) | 2198679..2199173 | + | 495 | WP_003899099.1 | hypothetical protein | - |
ORO20_RS10280 (ORO20_10280) | 2199333..2199740 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
ORO20_RS10285 (ORO20_10285) | 2199744..2200016 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
ORO20_RS10290 (ORO20_10290) | 2200049..2201269 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
ORO20_RS10295 (ORO20_10295) | 2202168..2202473 | + | 306 | Protein_2034 | ABC transporter permease | - |
ORO20_RS10300 (ORO20_10300) | 2202469..2202549 | + | 81 | Protein_2035 | hypothetical protein | - |
ORO20_RS10305 (ORO20_10305) | 2202657..2203505 | + | 849 | WP_010950638.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T265071 WP_003409896.1 NZ_CP112997:c2198444-2198148 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TLU9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BUZ2 |