Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2189111..2189814 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag ORO20_RS10175 Protein ID WP_003409778.1
Coordinates 2189111..2189440 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag ORO20_RS10180 Protein ID WP_003409780.1
Coordinates 2189437..2189814 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS10155 (ORO20_10155) 2185494..2186564 + 1071 WP_003899091.1 epoxide hydrolase EphB -
ORO20_RS10160 (ORO20_10160) 2186561..2187076 + 516 WP_003409718.1 flavin reductase family protein -
ORO20_RS10165 (ORO20_10165) 2187073..2188134 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
ORO20_RS10170 (ORO20_10170) 2188131..2188901 + 771 WP_003409775.1 SDR family oxidoreductase -
ORO20_RS10175 (ORO20_10175) 2189111..2189440 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ORO20_RS10180 (ORO20_10180) 2189437..2189814 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
ORO20_RS10185 (ORO20_10185) 2189811..2190401 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
ORO20_RS10190 (ORO20_10190) 2190456..2191820 + 1365 WP_003899094.1 HNH endonuclease signature motif containing protein -
ORO20_RS10195 (ORO20_10195) 2191975..2192427 - 453 WP_010950636.1 lipoprotein -
ORO20_RS10200 (ORO20_10200) 2192491..2192892 + 402 WP_003409869.1 hypothetical protein -
ORO20_RS10205 (ORO20_10205) 2192885..2193067 - 183 WP_003409870.1 hypothetical protein -
ORO20_RS10210 (ORO20_10210) 2193181..2193531 - 351 WP_003409871.1 hypothetical protein -
ORO20_RS10215 (ORO20_10215) 2193542..2194444 - 903 WP_003409874.1 hypothetical protein -
ORO20_RS10220 (ORO20_10220) 2194465..2194656 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T265069 WP_003409778.1 NZ_CP112997:c2189440-2189111 [Mycobacterium tuberculosis variant bovis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT265069 WP_003409780.1 NZ_CP112997:c2189814-2189437 [Mycobacterium tuberculosis variant bovis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References