Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1955864..1956324 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag ORO20_RS09165 Protein ID WP_003408531.1
Coordinates 1956076..1956324 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag ORO20_RS09160 Protein ID WP_003408528.1
Coordinates 1955864..1956076 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS09145 (ORO20_09145) 1952342..1953529 - 1188 WP_003898992.1 nitrate transporter NarK -
ORO20_RS09150 (ORO20_09150) 1953816..1954100 + 285 WP_003408522.1 DUF1876 domain-containing protein -
ORO20_RS09155 (ORO20_09155) 1954114..1955796 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
ORO20_RS09160 (ORO20_09160) 1955864..1956076 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ORO20_RS09165 (ORO20_09165) 1956076..1956324 + 249 WP_003408531.1 hypothetical protein Toxin
ORO20_RS09170 (ORO20_09170) 1956332..1957070 + 739 Protein_1809 hypothetical protein -
ORO20_RS09175 (ORO20_09175) 1957164..1958864 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
ORO20_RS09180 (ORO20_09180) 1959149..1959550 - 402 WP_010950586.1 hypothetical protein -
ORO20_RS09185 (ORO20_09185) 1959540..1960151 - 612 Protein_1812 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T265068 WP_003408531.1 NZ_CP112997:1956076-1956324 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT265068 WP_003408528.1 NZ_CP112997:1955864-1956076 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References