Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1573164..1573819 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag ORO20_RS07455 Protein ID WP_003407268.1
Coordinates 1573164..1573565 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag ORO20_RS07460 Protein ID WP_003407272.1
Coordinates 1573562..1573819 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS07440 (ORO20_07440) 1569008..1570393 - 1386 WP_003407260.1 cytochrome P450 -
ORO20_RS07445 (ORO20_07445) 1570471..1571505 + 1035 WP_003407264.1 AraC family transcriptional regulator -
ORO20_RS07450 (ORO20_07450) 1571551..1572909 - 1359 WP_010950541.1 PE family protein -
ORO20_RS07455 (ORO20_07455) 1573164..1573565 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO20_RS07460 (ORO20_07460) 1573562..1573819 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
ORO20_RS07465 (ORO20_07465) 1573902..1574861 - 960 WP_003407276.1 alpha/beta hydrolase -
ORO20_RS07470 (ORO20_07470) 1574886..1575848 - 963 WP_003407279.1 alpha/beta hydrolase -
ORO20_RS07475 (ORO20_07475) 1575847..1576584 + 738 WP_031647000.1 lysoplasmalogenase -
ORO20_RS07480 (ORO20_07480) 1576665..1578632 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T265064 WP_003407268.1 NZ_CP112997:c1573565-1573164 [Mycobacterium tuberculosis variant bovis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT265064 WP_003407272.1 NZ_CP112997:c1573819-1573562 [Mycobacterium tuberculosis variant bovis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References