Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1383885..1384573 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag ORO20_RS06630 Protein ID WP_003406304.1
Coordinates 1384142..1384573 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag ORO20_RS06625 Protein ID WP_003406302.1
Coordinates 1383885..1384145 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS06605 (ORO20_06605) 1379462..1380286 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
ORO20_RS06610 (ORO20_06610) 1380291..1381472 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
ORO20_RS06615 (ORO20_06615) 1381549..1382649 - 1101 WP_010950508.1 magnesium/cobalt transporter CorA -
ORO20_RS06620 (ORO20_06620) 1382820..1383809 + 990 WP_003406301.1 malate dehydrogenase -
ORO20_RS06625 (ORO20_06625) 1383885..1384145 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
ORO20_RS06630 (ORO20_06630) 1384142..1384573 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO20_RS06635 (ORO20_06635) 1384596..1386285 - 1690 Protein_1309 PE family protein -
ORO20_RS06640 (ORO20_06640) 1386465..1387325 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
ORO20_RS06645 (ORO20_06645) 1387406..1388236 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
ORO20_RS06650 (ORO20_06650) 1388293..1388586 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
ORO20_RS06655 (ORO20_06655) 1388583..1388852 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T265061 WP_003406304.1 NZ_CP112997:1384142-1384573 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT265061 WP_003406302.1 NZ_CP112997:1383885-1384145 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References