Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 3237791..3238452 | Replicon | chromosome |
Accession | NC_017322 | ||
Organism | Sinorhizobium meliloti BL225C |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q92KY5 |
Locus tag | SINMEB_RS15370 | Protein ID | WP_010970565.1 |
Coordinates | 3237791..3238195 (-) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q92KY4 |
Locus tag | SINMEB_RS15375 | Protein ID | WP_010970566.1 |
Coordinates | 3238192..3238452 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SINMEB_RS15355 | 3233334..3234446 | + | 1113 | WP_003535893.1 | 3-isopropylmalate dehydrogenase | - |
SINMEB_RS15360 | 3234575..3235282 | + | 708 | WP_010970563.1 | phosphatase PAP2 family protein | - |
SINMEB_RS15365 | 3235383..3237272 | - | 1890 | WP_014527006.1 | MHS family MFS transporter | - |
SINMEB_RS15370 | 3237791..3238195 | - | 405 | WP_010970565.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
SINMEB_RS15375 | 3238192..3238452 | - | 261 | WP_010970566.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
SINMEB_RS33700 | 3238581..3238751 | + | 171 | WP_010970567.1 | hypothetical protein | - |
SINMEB_RS15380 | 3238865..3239899 | + | 1035 | WP_003531790.1 | aspartate-semialdehyde dehydrogenase | - |
SINMEB_RS15385 | 3240072..3240893 | + | 822 | WP_010970568.1 | lytic transglycosylase family protein | - |
SINMEB_RS15390 | 3241240..3241923 | - | 684 | WP_010970569.1 | carbonic anhydrase | - |
SINMEB_RS15395 | 3242097..3242978 | - | 882 | WP_010970570.1 | pyridoxal kinase PdxY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14507.71 Da Isoelectric Point: 6.7257
>T26506 WP_010970565.1 NC_017322:c3238195-3237791 [Sinorhizobium meliloti BL225C]
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL
Download Length: 405 bp
>T26506 NC_017322:c3238195-3237791 [Sinorhizobium meliloti BL225C]
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9903.16 Da Isoelectric Point: 5.1253
>AT26506 WP_010970566.1 NC_017322:c3238452-3238192 [Sinorhizobium meliloti BL225C]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR
Download Length: 261 bp
>AT26506 NC_017322:c3238452-3238192 [Sinorhizobium meliloti BL225C]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGTCGGAA
CTCGACGCGGTATTTCGGTGA
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGTCGGAA
CTCGACGCGGTATTTCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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