265059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230327..1230958 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag ORO20_RS05900 Protein ID WP_003405820.1
Coordinates 1230327..1230638 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag ORO20_RS05905 Protein ID WP_003405836.1
Coordinates 1230638..1230958 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS05880 (ORO20_05880) 1225809..1227233 - 1425 WP_003405805.1 class II fumarate hydratase -
ORO20_RS05885 (ORO20_05885) 1227264..1228352 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
ORO20_RS05890 (ORO20_05890) 1228408..1229052 + 645 WP_003915494.1 DUF4245 domain-containing protein -
ORO20_RS05895 (ORO20_05895) 1229059..1230215 - 1157 Protein_1161 AI-2E family transporter -
ORO20_RS05900 (ORO20_05900) 1230327..1230638 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
ORO20_RS05905 (ORO20_05905) 1230638..1230958 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
ORO20_RS05910 (ORO20_05910) 1230968..1232504 + 1537 Protein_1164 carboxylesterase/lipase family protein -
ORO20_RS05915 (ORO20_05915) 1232511..1233623 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
ORO20_RS05920 (ORO20_05920) 1233633..1233890 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
ORO20_RS05925 (ORO20_05925) 1233880..1235127 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
ORO20_RS05930 (ORO20_05930) 1235124..1235762 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T265059 WP_003405820.1 NZ_CP112997:c1230638-1230327 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT265059 WP_003405836.1 NZ_CP112997:c1230958-1230638 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References