Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 443328..444339 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag ORO20_RS01945 Protein ID WP_003401859.1
Coordinates 443328..443921 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag ORO20_RS01950 Protein ID WP_003401860.1
Coordinates 443950..444339 (-) Length 130 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS01925 (ORO20_01925) 438977..440359 + 1383 WP_003898415.1 magnesium transporter -
ORO20_RS01930 (ORO20_01930) 440371..441405 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
ORO20_RS01935 (ORO20_01935) 441501..442184 + 684 WP_010950388.1 VTT domain-containing protein -
ORO20_RS01940 (ORO20_01940) 442173..443303 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
ORO20_RS01945 (ORO20_01945) 443328..443921 - 594 WP_003401859.1 zeta toxin family protein Toxin
ORO20_RS01950 (ORO20_01950) 443950..444339 - 390 WP_003401860.1 hypothetical protein Antitoxin
ORO20_RS01955 (ORO20_01955) 444420..445631 - 1212 WP_010950389.1 VWA domain-containing protein -
ORO20_RS01960 (ORO20_01960) 445637..446239 - 603 WP_003898417.1 SRPBCC family protein -
ORO20_RS01965 (ORO20_01965) 446253..447149 - 897 WP_003401863.1 MoxR family ATPase -
ORO20_RS01970 (ORO20_01970) 447146..447739 - 594 WP_003401864.1 NTP transferase domain-containing protein -
ORO20_RS01975 (ORO20_01975) 447736..448491 - 756 WP_010950390.1 XdhC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T265043 WP_003401859.1 NZ_CP112997:c443921-443328 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp


Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT265043 WP_003401860.1 NZ_CP112997:c444339-443950 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References