265042

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 362965..363608 Replicon chromosome
Accession NZ_CP112997
Organism Mycobacterium tuberculosis variant bovis strain 2016/0386

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag ORO20_RS01595 Protein ID WP_003401566.1
Coordinates 363183..363608 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag ORO20_RS01590 Protein ID WP_003401563.1
Coordinates 362965..363186 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO20_RS01565 (ORO20_01565) 358039..358842 - 804 WP_003401540.1 Stf0 family sulphotransferase -
ORO20_RS01570 (ORO20_01570) 358852..360249 - 1398 WP_003401544.1 sulfatase -
ORO20_RS01575 (ORO20_01575) 360428..362248 + 1821 WP_268141962.1 PE family protein -
ORO20_RS01580 (ORO20_01580) 362391..362618 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
ORO20_RS01585 (ORO20_01585) 362615..362917 + 303 WP_003401560.1 toxin-antitoxin system toxin -
ORO20_RS01590 (ORO20_01590) 362965..363186 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
ORO20_RS01595 (ORO20_01595) 363183..363608 + 426 WP_003401566.1 PIN domain nuclease Toxin
ORO20_RS01600 (ORO20_01600) 363743..364375 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
ORO20_RS01605 (ORO20_01605) 364372..365280 + 909 WP_003900117.1 protochlorophyllide reductase -
ORO20_RS01610 (ORO20_01610) 365288..365878 - 591 WP_234712434.1 hypothetical protein -
ORO20_RS01615 (ORO20_01615) 365871..365921 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T265042 WP_003401566.1 NZ_CP112997:363183-363608 [Mycobacterium tuberculosis variant bovis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT265042 WP_003401563.1 NZ_CP112997:362965-363186 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References