Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3755794..3756461 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag ORO19_RS17635 Protein ID WP_003417916.1
Coordinates 3755794..3756186 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag ORO19_RS17640 Protein ID WP_003912214.1
Coordinates 3756186..3756461 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS17620 (ORO19_17620) 3751164..3753002 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
ORO19_RS17625 (ORO19_17625) 3752999..3753988 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
ORO19_RS17630 (ORO19_17630) 3753988..3755040 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
ORO19_RS17635 (ORO19_17635) 3755794..3756186 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS17640 (ORO19_17640) 3756186..3756461 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ORO19_RS17645 (ORO19_17645) 3756643..3758014 + 1372 Protein_3485 ISNCY family transposase -
ORO19_RS17650 (ORO19_17650) 3758204..3760447 + 2244 WP_043856435.1 PE family protein -
ORO19_RS17655 (ORO19_17655) 3760518..3761390 - 873 WP_010950882.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3757337..3758014 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T265038 WP_003417916.1 NZ_CP112996:c3756186-3755794 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT265038 WP_003912214.1 NZ_CP112996:c3756461-3756186 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References