Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3728672..3729201 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag ORO19_RS17515 Protein ID WP_003417760.1
Coordinates 3728944..3729201 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag ORO19_RS17510 Protein ID WP_003417757.1
Coordinates 3728672..3728947 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS17475 (ORO19_17475) 3725245..3725934 - 690 WP_003917774.1 BBE domain-containing protein -
ORO19_RS17480 (ORO19_17480) 3726121..3726492 - 372 WP_003417739.1 FAD-binding protein -
ORO19_RS17485 (ORO19_17485) 3726390..3726608 - 219 WP_157132559.1 hypothetical protein -
ORO19_RS17490 (ORO19_17490) 3726635..3726895 - 261 WP_003417741.1 hypothetical protein -
ORO19_RS17495 (ORO19_17495) 3727010..3727399 + 390 WP_010950876.1 DUF732 domain-containing protein -
ORO19_RS17500 (ORO19_17500) 3727413..3727706 - 294 WP_003417749.1 DUF3017 domain-containing protein -
ORO19_RS17505 (ORO19_17505) 3727703..3728548 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
ORO19_RS17510 (ORO19_17510) 3728672..3728947 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
ORO19_RS17515 (ORO19_17515) 3728944..3729201 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
ORO19_RS17520 (ORO19_17520) 3729243..3730433 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
ORO19_RS17525 (ORO19_17525) 3730550..3730918 + 369 WP_003417765.1 FHA domain-containing protein -
ORO19_RS17530 (ORO19_17530) 3730915..3731466 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
ORO19_RS17535 (ORO19_17535) 3731473..3732054 - 582 WP_003417769.1 ATP/GTP-binding protein -
ORO19_RS17540 (ORO19_17540) 3732035..3732403 - 369 WP_003417772.1 DUF742 domain-containing protein -
ORO19_RS17545 (ORO19_17545) 3732381..3732773 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T265037 WP_003417760.1 NZ_CP112996:3728944-3729201 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT265037 WP_003417757.1 NZ_CP112996:3728672-3728947 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References