Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3143732..3144419 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag ORO19_RS14960 Protein ID WP_003414624.1
Coordinates 3143976..3144419 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag ORO19_RS14955 Protein ID WP_003414620.1
Coordinates 3143732..3143989 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS14935 (ORO19_14935) 3139052..3139906 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
ORO19_RS14940 (ORO19_14940) 3139962..3141125 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
ORO19_RS14945 (ORO19_14945) 3141142..3142356 - 1215 WP_003414610.1 zinc metalloprotease Rip -
ORO19_RS14950 (ORO19_14950) 3142364..3143605 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
ORO19_RS14955 (ORO19_14955) 3143732..3143989 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
ORO19_RS14960 (ORO19_14960) 3143976..3144419 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS14965 (ORO19_14965) 3144499..3145161 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
ORO19_RS14970 (ORO19_14970) 3145257..3145448 + 192 WP_023349587.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
ORO19_RS14975 (ORO19_14975) 3145780..3147528 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
ORO19_RS14980 (ORO19_14980) 3147624..3148205 + 582 WP_003414644.1 fasciclin domain-containing protein -
ORO19_RS14985 (ORO19_14985) 3148305..3148571 + 267 WP_031652375.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T265034 WP_003414624.1 NZ_CP112996:3143976-3144419 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT265034 WP_003414620.1 NZ_CP112996:3143732-3143989 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References