Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3138131..3138679 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag ORO19_RS14930 Protein ID WP_003414602.1
Coordinates 3138416..3138679 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag ORO19_RS14925 Protein ID WP_003414599.1
Coordinates 3138131..3138412 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS14900 (ORO19_14900) 3133754..3134611 - 858 WP_003899513.1 type I methionyl aminopeptidase -
ORO19_RS14905 (ORO19_14905) 3134653..3135237 - 585 WP_010950792.1 DUF1707 domain-containing protein -
ORO19_RS14910 (ORO19_14910) 3135341..3135589 + 249 WP_003913411.1 antitoxin VapB23 -
ORO19_RS14915 (ORO19_14915) 3135586..3135966 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
ORO19_RS14920 (ORO19_14920) 3136048..3137859 - 1812 WP_003414596.1 penicillin-binding protein -
ORO19_RS14925 (ORO19_14925) 3138131..3138412 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
ORO19_RS14930 (ORO19_14930) 3138416..3138679 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ORO19_RS14935 (ORO19_14935) 3139052..3139906 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
ORO19_RS14940 (ORO19_14940) 3139962..3141125 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
ORO19_RS14945 (ORO19_14945) 3141142..3142356 - 1215 WP_003414610.1 zinc metalloprotease Rip -
ORO19_RS14950 (ORO19_14950) 3142364..3143605 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T265033 WP_003414602.1 NZ_CP112996:3138416-3138679 [Mycobacterium tuberculosis variant bovis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT265033 WP_003414599.1 NZ_CP112996:3138131-3138412 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References