Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3071318..3071888 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag ORO19_RS14585 Protein ID WP_003414166.1
Coordinates 3071318..3071674 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag ORO19_RS14590 Protein ID WP_003901465.1
Coordinates 3071658..3071888 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS14565 (ORO19_14565) 3066764..3068452 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
ORO19_RS14570 (ORO19_14570) 3068456..3068782 - 327 WP_003414157.1 hypothetical protein -
ORO19_RS14575 (ORO19_14575) 3068955..3069548 + 594 WP_178136156.1 DUF3558 family protein -
ORO19_RS14580 (ORO19_14580) 3069567..3071216 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
ORO19_RS14585 (ORO19_14585) 3071318..3071674 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
ORO19_RS14590 (ORO19_14590) 3071658..3071888 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
ORO19_RS14595 (ORO19_14595) 3071931..3072974 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
ORO19_RS14600 (ORO19_14600) 3072973..3073440 + 468 WP_003414177.1 DUF1778 domain-containing protein -
ORO19_RS14605 (ORO19_14605) 3073616..3073870 - 255 WP_003917684.1 hypothetical protein -
ORO19_RS14610 (ORO19_14610) 3074018..3074422 + 405 WP_003414181.1 hypothetical protein -
ORO19_RS14615 (ORO19_14615) 3074419..3074610 + 192 WP_003414184.1 hypothetical protein -
ORO19_RS14620 (ORO19_14620) 3074827..3075087 + 261 Protein_2885 transposase -
ORO19_RS14625 (ORO19_14625) 3076197..3076454 + 258 WP_003899489.1 hypothetical protein -
ORO19_RS14630 (ORO19_14630) 3076559..3076870 + 312 WP_010950777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T265030 WP_003414166.1 NZ_CP112996:c3071674-3071318 [Mycobacterium tuberculosis variant bovis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT265030 WP_003901465.1 NZ_CP112996:c3071888-3071658 [Mycobacterium tuberculosis variant bovis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References