Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2841749..2842386 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag ORO19_RS13335 Protein ID WP_003413180.1
Coordinates 2841749..2842144 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag ORO19_RS13340 Protein ID WP_003413183.1
Coordinates 2842141..2842386 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS13295 (ORO19_13295) 2837834..2838493 + 660 WP_031702625.1 LppA family lipoprotein -
ORO19_RS13300 (ORO19_13300) 2838490..2839149 + 660 WP_003900847.1 LppA family lipoprotein -
ORO19_RS13305 (ORO19_13305) 2839146..2839808 + 663 WP_003900848.1 LppA family lipoprotein -
ORO19_RS13310 (ORO19_13310) 2839805..2840083 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
ORO19_RS13315 (ORO19_13315) 2840176..2840589 + 414 WP_003413164.1 PIN domain nuclease -
ORO19_RS13320 (ORO19_13320) 2840628..2840885 + 258 WP_003413167.1 CopG family transcriptional regulator -
ORO19_RS13325 (ORO19_13325) 2840882..2841259 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
ORO19_RS13330 (ORO19_13330) 2841275..2841649 - 375 WP_003413177.1 hypothetical protein -
ORO19_RS13335 (ORO19_13335) 2841749..2842144 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
ORO19_RS13340 (ORO19_13340) 2842141..2842386 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
ORO19_RS13345 (ORO19_13345) 2842797..2843216 - 420 WP_003413190.1 A24 family peptidase -
ORO19_RS13350 (ORO19_13350) 2843228..2844036 - 809 Protein_2635 shikimate dehydrogenase -
ORO19_RS13355 (ORO19_13355) 2844033..2845286 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
ORO19_RS13360 (ORO19_13360) 2845279..2845791 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T265026 WP_003413180.1 NZ_CP112996:c2842144-2841749 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT265026 WP_003413183.1 NZ_CP112996:c2842386-2842141 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References