Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2779449..2780101 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag ORO19_RS13030 Protein ID WP_003412752.1
Coordinates 2779676..2780101 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag ORO19_RS13025 Protein ID WP_003412749.1
Coordinates 2779449..2779670 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS13010 (ORO19_13010) 2777689..2777895 - 207 WP_003899347.1 hypothetical protein -
ORO19_RS13015 (ORO19_13015) 2778031..2778654 + 624 WP_003900858.1 TIGR00725 family protein -
ORO19_RS13020 (ORO19_13020) 2778644..2779396 + 753 WP_003901416.1 hypothetical protein -
ORO19_RS13025 (ORO19_13025) 2779449..2779670 + 222 WP_003412749.1 antitoxin Antitoxin
ORO19_RS13030 (ORO19_13030) 2779676..2780101 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS13035 (ORO19_13035) 2780124..2781305 - 1182 WP_010950729.1 dihydrolipoamide acetyltransferase family protein -
ORO19_RS13040 (ORO19_13040) 2781302..2782348 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
ORO19_RS13045 (ORO19_13045) 2782359..2783462 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
ORO19_RS13050 (ORO19_13050) 2783721..2784542 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
ORO19_RS13055 (ORO19_13055) 2784539..2785096 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T265022 WP_003412752.1 NZ_CP112996:2779676-2780101 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT265022 WP_003412749.1 NZ_CP112996:2779449-2779670 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References