Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2309277..2309913 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag ORO19_RS10780 Protein ID WP_003410654.1
Coordinates 2309503..2309913 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag ORO19_RS10775 Protein ID WP_003410651.1
Coordinates 2309277..2309510 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS10760 (ORO19_10760) 2304725..2305126 + 402 WP_009937711.1 metal ABC transporter permease -
ORO19_RS10765 (ORO19_10765) 2305127..2305531 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
ORO19_RS10770 (ORO19_10770) 2305615..2309199 - 3585 WP_010950652.1 cobaltochelatase subunit CobN -
ORO19_RS10775 (ORO19_10775) 2309277..2309510 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
ORO19_RS10780 (ORO19_10780) 2309503..2309913 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
ORO19_RS10785 (ORO19_10785) 2309897..2310988 + 1092 WP_003900454.1 precorrin-3B synthase -
ORO19_RS10790 (ORO19_10790) 2310998..2311622 + 625 Protein_2133 precorrin-8X methylmutase -
ORO19_RS10795 (ORO19_10795) 2311619..2313145 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
ORO19_RS10800 (ORO19_10800) 2313091..2314314 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T265019 WP_003410654.1 NZ_CP112996:2309503-2309913 [Mycobacterium tuberculosis variant bovis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT265019 WP_003410651.1 NZ_CP112996:2309277-2309510 [Mycobacterium tuberculosis variant bovis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References