Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2241492..2242118 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag ORO19_RS10490 Protein ID WP_003410075.1
Coordinates 2241720..2242118 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ORO19_RS10485 Protein ID WP_019283586.1
Coordinates 2241492..2241719 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS10475 (ORO19_10475) 2239531..2239875 - 345 WP_003410065.1 ferredoxin family protein -
ORO19_RS10480 (ORO19_10480) 2240064..2241233 - 1170 WP_003899126.1 ATP-binding protein -
ORO19_RS10485 (ORO19_10485) 2241492..2241719 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ORO19_RS10490 (ORO19_10490) 2241720..2242118 + 399 WP_003410075.1 PIN domain nuclease Toxin
ORO19_RS10495 (ORO19_10495) 2242301..2242732 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
ORO19_RS10500 (ORO19_10500) 2242881..2243267 + 387 WP_003899128.1 DUF1398 domain-containing protein -
ORO19_RS10505 (ORO19_10505) 2243704..2243883 - 180 Protein_2076 hypothetical protein -
ORO19_RS10510 (ORO19_10510) 2243971..2244591 + 621 WP_043856400.1 IS110 family transposase -
ORO19_RS10515 (ORO19_10515) 2244545..2245135 + 591 WP_043856401.1 IS110 family transposase -
ORO19_RS10520 (ORO19_10520) 2245263..2246519 - 1257 WP_010950642.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T265017 WP_003410075.1 NZ_CP112996:2241720-2242118 [Mycobacterium tuberculosis variant bovis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT265017 WP_019283586.1 NZ_CP112996:2241492-2241719 [Mycobacterium tuberculosis variant bovis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References