Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2208860..2209548 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag ORO19_RS10320 Protein ID WP_003409958.1
Coordinates 2208860..2209279 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag ORO19_RS10325 Protein ID WP_003409968.1
Coordinates 2209288..2209548 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS10290 (ORO19_10290) 2203866..2204171 + 306 Protein_2033 ABC transporter permease -
ORO19_RS10295 (ORO19_10295) 2204167..2204247 + 81 Protein_2034 hypothetical protein -
ORO19_RS10300 (ORO19_10300) 2204355..2205203 + 849 WP_010950638.1 class I SAM-dependent methyltransferase -
ORO19_RS10305 (ORO19_10305) 2205166..2206611 - 1446 WP_003409946.1 APC family permease -
ORO19_RS10310 (ORO19_10310) 2206790..2207476 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
ORO19_RS10315 (ORO19_10315) 2207667..2208635 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
ORO19_RS10320 (ORO19_10320) 2208860..2209279 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS10325 (ORO19_10325) 2209288..2209548 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ORO19_RS10330 (ORO19_10330) 2209691..2211367 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
ORO19_RS10335 (ORO19_10335) 2211355..2212008 - 654 WP_003409976.1 cutinase Cfp21 -
ORO19_RS10340 (ORO19_10340) 2212123..2212353 + 231 WP_003409980.1 DUF167 domain-containing protein -
ORO19_RS10345 (ORO19_10345) 2212438..2213349 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
ORO19_RS10350 (ORO19_10350) 2213458..2214057 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T265014 WP_003409958.1 NZ_CP112996:c2209279-2208860 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT265014 WP_003409968.1 NZ_CP112996:c2209548-2209288 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References