Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1957568..1958028 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag ORO19_RS09160 Protein ID WP_003408531.1
Coordinates 1957780..1958028 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag ORO19_RS09155 Protein ID WP_003408528.1
Coordinates 1957568..1957780 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS09140 (ORO19_09140) 1954046..1955233 - 1188 WP_003898992.1 nitrate transporter NarK -
ORO19_RS09145 (ORO19_09145) 1955520..1955804 + 285 WP_003408522.1 DUF1876 domain-containing protein -
ORO19_RS09150 (ORO19_09150) 1955818..1957500 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
ORO19_RS09155 (ORO19_09155) 1957568..1957780 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ORO19_RS09160 (ORO19_09160) 1957780..1958028 + 249 WP_003408531.1 hypothetical protein Toxin
ORO19_RS09165 (ORO19_09165) 1958036..1958774 + 739 Protein_1808 hypothetical protein -
ORO19_RS09170 (ORO19_09170) 1958868..1960568 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
ORO19_RS09175 (ORO19_09175) 1960853..1961254 - 402 WP_010950586.1 hypothetical protein -
ORO19_RS09180 (ORO19_09180) 1961244..1961855 - 612 Protein_1811 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T265010 WP_003408531.1 NZ_CP112996:1957780-1958028 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT265010 WP_003408528.1 NZ_CP112996:1957568-1957780 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References