26501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 960281..960855 Replicon chromosome
Accession NC_017322
Organism Sinorhizobium meliloti BL225C

Toxin (Protein)


Gene name vapC Uniprot ID Q92QN4
Locus tag SINMEB_RS04535 Protein ID WP_010969154.1
Coordinates 960281..960646 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92QN3
Locus tag SINMEB_RS04540 Protein ID WP_010969155.1
Coordinates 960640..960855 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINMEB_RS04510 955421..956863 + 1443 WP_014526682.1 NADH-quinone oxidoreductase subunit NuoN -
SINMEB_RS04515 956860..957627 + 768 WP_003531861.1 biotin--[acetyl-CoA-carboxylase] ligase -
SINMEB_RS04520 957655..959322 + 1668 WP_010969151.1 ribonuclease J -
SINMEB_RS04525 959381..959785 + 405 WP_010969152.1 methylmalonyl-CoA epimerase -
SINMEB_RS04530 959925..960194 + 270 WP_014526683.1 DUF1467 family protein -
SINMEB_RS04535 960281..960646 - 366 WP_010969154.1 type II toxin-antitoxin system VapC family toxin Toxin
SINMEB_RS04540 960640..960855 - 216 WP_010969155.1 ribbon-helix-helix protein, CopG family Antitoxin
SINMEB_RS04545 960923..961150 - 228 WP_017264047.1 hypothetical protein -
SINMEB_RS04550 961566..962894 + 1329 WP_003531873.1 proline--tRNA ligase -
SINMEB_RS04555 962915..964225 + 1311 WP_014529722.1 lipoprotein-releasing ABC transporter permease subunit -
SINMEB_RS04560 964243..964929 + 687 WP_010969157.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13592.57 Da        Isoelectric Point: 5.1787

>T26501 WP_010969154.1 NC_017322:c960646-960281 [Sinorhizobium meliloti BL225C]
MVGALFDTNILIDHLNAVPQAHKELDRFENRAISIITWMEVMVGADAELVEPTRRFLDGFETIALNDEIANRAVTLRRAH
RIKLPDAVIWATAQTAGRLLVTRNTKDFPADDPGIREPYAV

Download         Length: 366 bp

>T26501 NC_017322:c960646-960281 [Sinorhizobium meliloti BL225C]
ATGGTAGGCGCACTGTTCGATACCAATATCCTTATCGATCATCTGAATGCGGTGCCTCAGGCGCACAAGGAACTTGACCG
TTTCGAAAACCGGGCCATCAGCATCATCACCTGGATGGAGGTGATGGTTGGAGCGGACGCCGAACTGGTTGAGCCGACCC
GGCGCTTCCTCGACGGTTTCGAAACGATCGCCTTGAACGATGAGATCGCCAACCGTGCGGTGACATTGCGCAGGGCGCAC
CGCATCAAGCTACCCGACGCGGTGATCTGGGCAACGGCGCAGACTGCCGGTCGTCTGCTCGTGACGCGCAATACCAAGGA
CTTTCCAGCCGACGACCCGGGGATACGCGAACCCTACGCCGTGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8381.51 Da        Isoelectric Point: 8.6052

>AT26501 WP_010969155.1 NC_017322:c960855-960640 [Sinorhizobium meliloti BL225C]
MRALIDMNDTQVEALDTLAKRVRRSRAALIREAIDDYLNRHHREQIEDGFGLWGKRKVDGLAYQEKVRGEW

Download         Length: 216 bp

>AT26501 NC_017322:c960855-960640 [Sinorhizobium meliloti BL225C]
ATGCGAGCCTTGATCGATATGAACGATACCCAGGTCGAAGCCCTAGATACCCTCGCCAAGCGGGTGCGCCGGTCCCGTGC
GGCTCTGATCCGCGAAGCGATCGACGACTATCTCAACCGTCATCATCGCGAGCAGATCGAAGATGGCTTCGGTTTGTGGG
GCAAGCGCAAAGTTGACGGTCTGGCTTATCAGGAGAAGGTGCGCGGCGAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92QN4

Antitoxin

Source ID Structure
AlphaFold DB Q92QN3

References