Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1936836..1937449 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag ORO19_RS09050 Protein ID WP_003408465.1
Coordinates 1936836..1937225 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag ORO19_RS09055 Protein ID WP_003408469.1
Coordinates 1937222..1937449 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS09015 (ORO19_09015) 1932466..1933380 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
ORO19_RS09020 (ORO19_09020) 1933383..1934213 + 831 WP_003408448.1 cyclase family protein -
ORO19_RS09025 (ORO19_09025) 1934213..1934563 + 351 WP_003898986.1 cupin domain-containing protein -
ORO19_RS09030 (ORO19_09030) 1934616..1935433 + 818 Protein_1782 3-keto-5-aminohexanoate cleavage protein -
ORO19_RS09035 (ORO19_09035) 1935447..1936226 + 780 WP_003408460.1 IclR family transcriptional regulator -
ORO19_RS09045 (ORO19_09045) 1936657..1936788 + 132 Protein_1784 IS3 family transposase -
ORO19_RS09050 (ORO19_09050) 1936836..1937225 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS09055 (ORO19_09055) 1937222..1937449 - 228 WP_003408469.1 antitoxin Antitoxin
ORO19_RS09060 (ORO19_09060) 1937667..1939151 + 1485 WP_010950580.1 biotin carboxylase -
ORO19_RS09065 (ORO19_09065) 1939148..1940395 + 1248 WP_003408476.1 serine hydrolase -
ORO19_RS09070 (ORO19_09070) 1940438..1940857 - 420 WP_003408483.1 hypothetical protein -
ORO19_RS09075 (ORO19_09075) 1940847..1941557 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T265009 WP_003408465.1 NZ_CP112996:c1937225-1936836 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT265009 WP_003408469.1 NZ_CP112996:c1937449-1937222 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References