Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1687483..1688099 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag ORO19_RS07950 Protein ID WP_003407593.1
Coordinates 1687782..1688099 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag ORO19_RS07945 Protein ID WP_003900349.1
Coordinates 1687483..1687785 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS07935 (ORO19_07935) 1683369..1685216 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
ORO19_RS07940 (ORO19_07940) 1685217..1687469 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
ORO19_RS07945 (ORO19_07945) 1687483..1687785 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
ORO19_RS07950 (ORO19_07950) 1687782..1688099 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
ORO19_RS07955 (ORO19_07955) 1688096..1689100 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
ORO19_RS07960 (ORO19_07960) 1689153..1690442 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
ORO19_RS07965 (ORO19_07965) 1690515..1691240 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
ORO19_RS07970 (ORO19_07970) 1691346..1691537 - 192 WP_003407609.1 dodecin family protein -
ORO19_RS07975 (ORO19_07975) 1691619..1692017 + 399 WP_003900351.1 hypothetical protein -
ORO19_RS07980 (ORO19_07980) 1692062..1693090 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T265007 WP_003407593.1 NZ_CP112996:1687782-1688099 [Mycobacterium tuberculosis variant bovis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT265007 WP_003900349.1 NZ_CP112996:1687483-1687785 [Mycobacterium tuberculosis variant bovis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References