Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1574879..1575534 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag ORO19_RS07450 Protein ID WP_003407268.1
Coordinates 1574879..1575280 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag ORO19_RS07455 Protein ID WP_003407272.1
Coordinates 1575277..1575534 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS07435 (ORO19_07435) 1570723..1572108 - 1386 WP_003407260.1 cytochrome P450 -
ORO19_RS07440 (ORO19_07440) 1572186..1573220 + 1035 WP_003407264.1 AraC family transcriptional regulator -
ORO19_RS07445 (ORO19_07445) 1573266..1574624 - 1359 WP_010950541.1 PE family protein -
ORO19_RS07450 (ORO19_07450) 1574879..1575280 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS07455 (ORO19_07455) 1575277..1575534 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
ORO19_RS07460 (ORO19_07460) 1575617..1576576 - 960 WP_003407276.1 alpha/beta hydrolase -
ORO19_RS07465 (ORO19_07465) 1576601..1577563 - 963 WP_003407279.1 alpha/beta hydrolase -
ORO19_RS07470 (ORO19_07470) 1577562..1578299 + 738 WP_031647000.1 lysoplasmalogenase -
ORO19_RS07475 (ORO19_07475) 1578380..1580347 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T265006 WP_003407268.1 NZ_CP112996:c1575280-1574879 [Mycobacterium tuberculosis variant bovis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT265006 WP_003407272.1 NZ_CP112996:c1575534-1575277 [Mycobacterium tuberculosis variant bovis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References