Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1540885..1541935 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag ORO19_RS07300 Protein ID WP_003407164.1
Coordinates 1540885..1541706 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag ORO19_RS07305 Protein ID WP_003407167.1
Coordinates 1541699..1541935 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS07280 (ORO19_07280) 1536443..1537105 - 663 WP_010950531.1 hypothetical protein -
ORO19_RS07285 (ORO19_07285) 1537102..1537887 - 786 WP_010950532.1 hypothetical protein -
ORO19_RS07290 (ORO19_07290) 1538178..1540139 - 1962 WP_010950533.1 sigma-F factor regulator -
ORO19_RS07295 (ORO19_07295) 1540278..1540664 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
ORO19_RS07300 (ORO19_07300) 1540885..1541706 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
ORO19_RS07305 (ORO19_07305) 1541699..1541935 + 237 WP_003407167.1 hypothetical protein Antitoxin
ORO19_RS07310 (ORO19_07310) 1542007..1543212 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
ORO19_RS07315 (ORO19_07315) 1543515..1544300 + 786 WP_003407180.1 lipoprotein LprF -
ORO19_RS07320 (ORO19_07320) 1544496..1545966 + 1471 Protein_1441 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T265005 WP_003407164.1 NZ_CP112996:1540885-1541706 [Mycobacterium tuberculosis variant bovis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT265005 WP_003407167.1 NZ_CP112996:1541699-1541935 [Mycobacterium tuberculosis variant bovis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References