Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1385601..1386289 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag ORO19_RS06625 Protein ID WP_003406304.1
Coordinates 1385858..1386289 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag ORO19_RS06620 Protein ID WP_003406302.1
Coordinates 1385601..1385861 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS06600 (ORO19_06600) 1381178..1382002 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
ORO19_RS06605 (ORO19_06605) 1382007..1383188 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
ORO19_RS06610 (ORO19_06610) 1383265..1384365 - 1101 WP_010950508.1 magnesium/cobalt transporter CorA -
ORO19_RS06615 (ORO19_06615) 1384536..1385525 + 990 WP_003406301.1 malate dehydrogenase -
ORO19_RS06620 (ORO19_06620) 1385601..1385861 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
ORO19_RS06625 (ORO19_06625) 1385858..1386289 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS06630 (ORO19_06630) 1386312..1388000 - 1689 WP_003910308.1 PE family protein -
ORO19_RS06635 (ORO19_06635) 1388180..1389040 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
ORO19_RS06640 (ORO19_06640) 1389121..1389951 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
ORO19_RS06645 (ORO19_06645) 1390008..1390301 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
ORO19_RS06650 (ORO19_06650) 1390298..1390567 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T265003 WP_003406304.1 NZ_CP112996:1385858-1386289 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT265003 WP_003406302.1 NZ_CP112996:1385601-1385861 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References